Mirtazapine tablets are used for the treatment of depression and can be taken orally by swallowing with water and not chewing. The effective oral dose is usually 15-45 mg per day, and care should be taken in patients with hepatic or renal impairment as the clearance of mirtazapine is reduced. Mirtazapine has a half-life of 20-40 hours and can be administered to infants once a day, preferably before bedtime, or in divided doses, once in the morning and once in the evening. Patients should continue to take the drug, preferably for 4-6 months after symptoms have completely disappeared before discontinuing it. The appropriate dose will have a significant effect within 2-4 weeks. If the effect is not significant, the dose can be increased up to the maximum dose. If there is no significant efficacy within 2-4 weeks after dose increase, the drug should be discontinued immediately. The usual adverse effects of mirtazapine include increased appetite and weight gain, drowsiness, and sedation, which usually occur within 1 week after taking the drug.