Urticaria is a limited edema that occurs in the skin mucosa due to a temporary increase in vascular permeability. Topical ointments include doxepin hydrochloride cream, compound benadryl application, and cyproheptadine cream. Doxepin Hydrochloride Cream: It has the effect of blocking H1 and H2 receptors, and is also a cholinergic receptor and adrenergic receptor antagonist, which can relieve the itching caused by urticaria. Compound Benzhydramine Application: is a compound preparation with pain-relieving, anti-itching and anti-inflammatory effects, which can be used for itchy skin symptoms caused by atopic dermatitis and urticaria. Cyproheptadine cream: it is a kind of antihistamine, which can relieve the allergic reaction caused by histamine, and can be used for allergic dermatitis, papular urticaria and pruritus. It is recommended that patients seek medical treatment in a timely manner, under the guidance of a professional physician, the use of drugs need to follow the doctor’s instructions, not blindly use their own medication, resulting in adverse consequences.