Recently, Xiao Wang is always woken up at night by a violent cough, accompanied by bitter mouth acid reflux. As the coughing affects his rest, he went to the hospital to see a doctor. At the hospital triage desk, he informed the receptionist that he wanted to see the cough, so he took the respiratory department’s number, and on the doctor’s advice, took a chest X-ray and checked his blood. The chest X-ray results showed no obvious abnormalities, and the blood tests showed some slight abnormalities, so the doctor prescribed some anti-inflammatory medication. After taking the medicine for a week, the coughing symptom still continued, the cough was very much up and there was pain in the throat. What to do? He came to the respiratory department for follow-up, the doctor was very responsible for him to do the examination, because some bronchitis or pneumonia symptoms appear in the early stage of the disease, it may be more difficult to find the disease on filming, so further to do a CT lungs, and the results show that there is no abnormality, that is, normal. What should be done next? Based on the fact that he also had a sore throat, the respiratory doctor recommended that he go to a laryngologist, perhaps due to a laryngitis problem. When he arrived at the ENT department, after the doctor’s examination, it was true that Xiao Wang also had pharyngitis, and the doctor gave him some medicine for pharyngitis. After using the medicine, the miracle didn’t appear, and the cough was still bothering Xiao Wang. The problem is not solved, still need to find a doctor. Who? Luckily, he came to the hospital again and went to the ENT department. The experienced doctor, based on his consultation process, thought he might have a special kind of gastric disease, so he changed to the gastroenterology department. After a gastroscopy, he already had esophagitis, a form of GERD. Subsequently, of course, the good news is that through targeted treatment, Xiaoliu not only got better from esophagitis, but also from coughing. Ren Hongyu, Department of Gastroenterology, Wuhan Union Medical College Hospital, Wuhan, China Gastroesophageal reflux disease (GERD) is a kind of esophagogastric dysfunction, during the relaxation of the lower esophageal dilator muscle (LES), the gastric contents reflux into the esophagus is known as GER, there are two kinds of physiological reflux and pathologic reflux in GERD, physiological reflux is caused by the LES spontaneously relaxation, which is conducive to the gastric gas discharge, the esophagus will appear to push peristalsis to push the gastric fluid into the esophagus. The esophagus will have peristaltic movement to push the gastric juice into the stomach, which normally does not cause damage to the esophageal lining. Pathologic reflux is a pathological phenomenon caused by multiple factors that result in gastroesophageal anti-reflux insufficiency. Gastroesophageal reflux disease (GERD) is a disease caused by the reflux of gastric or duodenal contents into the esophagus, which is often combined with esophagitis, and its continued development can lead to serious complications, such as: esophageal stenosis, ulcers, hemorrhage, and Barrett’s esophagus, the latter of which is a pre-cancerous condition, and extra-esophageal complications, such as acidic laryngitis, respiratory spasm and coughing, and lung injury complications, may also occur. The main manifestations of the disease are acid reflux, hiccups, and reflux of food in mild cases, reflux of acidic and bitter tasting gastric juices or flow of gastric juices into the mouth when bending over. Heavy acid reflux can be at night when sleeping, acidic irritants jet reflux to the throat caused by choking, wheezing or a sense of suffocation, but also due to esophageal acid reflux, reflexively cause excessive secretion of saliva, reflux food is generally seen in the heavier people, the food has a strong acidic flavor. Why do some patients show heavier respiratory symptoms? This is because the lungs to a small amount of inhalation of gastric reflux, acid and enzymes within the gastric juice to produce damage caused by pharyngolaryngitis; gastric reflux, stimulation of the esophagus secondary to neurally regulated reflex bronchoconstriction, which can cause coughing, bronchial asthma, choking, etc., and some patients with respiratory symptoms are mainly sore throat, hissing, difficulty in pronouncing words, and oropharyngeal symptoms: excessive salivation, dental damage, periodontal disease, otitis media, etc. Avoiding Mental Avoid high tension and diet irregularity and oversatiety, eat less sour, spicy, sweet, indigestible food, avoid strong tea, coffee, chocolate, etc., avoid smoking, drinking or eating high-fat food and often take calcium channel blockers, obese people should reduce their weight, the diet should be a small amount of meals, 4-6 meals a day, elevate the head of the bed 15-20CM when sleeping to reduce reflux. Ren Hongyu, Associate Professor, Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.