Membranous nephropathy antiphospholipase A2 receptor antibody turns negative meaning suggesting improvement of the disease. Positive anti-phospholipase A2 receptor antibody in membranous nephropathy is a specific indicator for the diagnosis of idiopathic membranous nephropathy with good sensitivity and specificity. Positive antiphospholipase A2 receptor antibody is a specific indicator of idiopathic membranous nephropathy with good sensitivity and specificity. The level of anti-phospholipase A2 receptor antibody in membranous nephropathy is also positively correlated with the severity of the disease, and the more severe the disease is, the higher the level of this indicator is. Therefore, this index can be used as an indicator for the treatment and prognosis of membranous nephropathy. If the anti-phospholipase A2 receptor antibody of membranous nephropathy turns from positive to negative, it indicates that the condition of membranous nephropathy improves, which means that the current medication is effective. At this time, you need to continue to take the medication in accordance with the doctor’s instructions, but you should not stop taking the medication because of the indicator turns to be negative, so as to avoid the disease from recurring. It is recommended that patients with membranous nephropathy go to the hospital for treatment under the guidance of the doctor, and do not stop or reduce the medication without authorization, so as to avoid delaying the condition.