Conditions diagnosed and treated in pain medicine are usually characterized by the presence of pain. Either chronic and prolonged pain, or pain that lasts only a few days but is severe and cannot be resolved by the usual medical and surgical methods. So how do we pain physicians treat patients today? Pain is usually difficult to treat when the cause of the pain is clear. For example, in the case of neuralgia caused by herpes zoster in the elderly, the pain is caused by the herpes zoster virus that infiltrates the nerves and causes pathological changes in the nervous system. Diseases whose causes are considered less clear by physicians in other departments and for which we can identify the cause after outpatient examination. For example, we can usually identify the cause of neck and shoulder pain and provide effective treatment. This is because we have found some new causes of these diseases based on the experience of our predecessors and textbooks, and these causes can usually be solved by our common local blocking techniques, local release techniques and local minimally invasive treatment techniques, and the practice of treating these diseases for many times has made us have a clearer and clearer understanding of these originally unknown causes of pain. Some patients with low back pain and lumbosacral pain also have this characteristic. Some pains have been troubling the patients for a long time but the diagnosis is unknown from many sides and the treatment is ineffective. In this case, we can use the original examination and treatment to exclude some diseases, especially after excluding some life-threatening diseases, we can directly target the pain with medication analgesia (targeted medication, adequate dose and combination of medication), local pain blocking, and pain control with implantation devices. These methods can also be used for pain that has a clear cause but is difficult to control. In conclusion, it is important to try to clarify the diagnosis and treat the cause aggressively to ensure pain relief and elimination. Physical, pharmacological and injectable, minimally invasive methods are used to solve the problem.