Skin rejection with itching sensation after leukemia transplantation is mainly treated by daily life care and medication, such as adjusting immunosuppressant medication and topical dexamethasone cream. 1. Daily life care: after leukemia transplantation, skin rejection with itching sensation, the diet should be light in daily life, avoiding the intake of stimulating and spicy food. Pay attention to the cleanliness of clothes and take bath frequently. 2. Medication: Immunosuppressant medication can be adjusted under the guidance of physicians, such as cyclosporine capsules, tacrolimus capsules and other oral dosage; topical medications such as dexamethasone ointment, budesonide ointment, haldolimusine ointment and so on can also be used. If the above symptoms occur, it is recommended to go to the hospital in time for early and regular treatment. All of the above medications should be used under the guidance of a doctor, avoid self-medication.