Whether the patient’s uric acid 476μmol/L is serious or not should be analyzed depending on whether the patient suffers from gout, gouty nephropathy, acute renal failure or concurrent metabolic diseases, cardiovascular and cerebral vascular diseases and other factors, and cannot be generalized. Regardless of the severity of the disease, uric acid 476μmol/L can be normalized with timely and regular treatment. The diagnostic criterion of blood uric acid for hyperuricemia is that the blood uric acid level is greater than 420 μmol/L when measured on two fasting occasions not on the same day under normal diet; therefore, the patient’s uric acid 476 μmol/L meets the diagnostic criterion of hyperuricemia, which belongs to the elevation of uric acid. If the patient has no complication or secondary gouty nephropathy, cardiovascular and cerebrovascular diseases and other diseases, it is not considered serious, but at the same time it should be treated for lowering uric acid; if the patient’s uric acid 476 μmol / L at the same time also complication or secondary gout, gouty nephropathy, cardiovascular and cerebrovascular diseases, acute renal failure, metabolic diseases, etc, it is relatively serious, and need to be timely treatment. Regardless of whether the condition is serious or not, uric acid 476μmol / L by timely and regular treatment, blood uric acid levels can mostly return to normal levels. At the same time, patients with high uric acid need to pay attention to avoid high-purine diet, such as seafood, animal offal, etc., quit drinking and reduce weight, and ensure that the daily water intake is more than 2000ml. It is recommended that patients with uric acid 476μmol/L should go to endocrinology and rheumatology department of regular hospitals for further consultation in order to avoid delay.