Skin flesh pain is caused by the following factors: 1, the most common factor is the infectious factor, regardless of bacterial, viral, fungal and atypical pathogens infection, there will be skin flesh pain inflammatory infection symptoms, because the inflammatory factors released during the infection, such as interleukin VI, bradykinin, tumor necrosis factor, leukotriene, histamine and other substances, such substances will cause skin flesh pain and inflammatory irritation reaction, will lead to surrounding redness, swelling, heat, pain, and joint dysfunction.2. The common cause of dermatome pain is allergic factors, and pain in the dermatome can also occur when the skin and soft tissues are allergic, when there is also a severe burning sensation.3. There are also connective tissue diseases, rheumatic diseases and other factors, such as common rheumatoid arthritis, rheumatoid arthritis, dermatomyositis, etc., which can have clinical manifestations of dermatome pain.