The cost of quadruple therapy varies from a few hundred to a thousand depending on the drugs chosen. Quadruple therapy is a way of combining drugs for the treatment of gastrointestinal disease patients after confirming the positive infection of Helicobacter pylori, mainly to protect the gastric mucosa on the premise of the complete elimination of Helicobacter pylori, in order to achieve the effect of eliminating the cause of the disease. The drug combination is composed of one proton pump inhibitor (PPI) (omeprazole, pantoprazole, esomeprazole, etc.), one bismuth agent (bismuth potassium citrate), and two antimicrobial drugs (amoxicillin, clarithromycin, roxithromycin, levofloxacin, metronidazole, etc.). The treatment cycle usually ranges from 10-14 days, and at the end of the treatment cycle, a carbon 13 breath test should be performed again after stopping the medication for 1 month to confirm whether the H. pylori bacteria have been eliminated. Any physical discomfort should be treated in a timely manner so as not to delay the development of the disease.