Mild diffuse echogenic changes in the liver parenchyma are findings on ultrasound of the liver and are usually indicative of hepatocellular damage. Diffuse hepatic parenchymal change is due to long-term chronic inflammation of the liver caused by liver injury, is a kind of organic changes, fatty liver, viral hepatitis, cirrhosis and other diseases will appear this manifestation, for the detection of diffuse liver injury patients, we should pay attention to the results of this examination, to prevent the occurrence of cirrhosis disease. The specific degree of liver damage and disease progression should be assessed in combination with other indicators, such as liver and gallbladder CT, liver function, liver fibrosis ultrasound, hepatitis viral screening, and so on. It is recommended that patients actively consult the doctor to further improve the relevant examinations, in order to clarify the cause of the disease, systematic diagnosis and treatment, and do not be negligent, so as not to delay the condition.