Leg pain at night can not sleep may be caused by physiological factors such as cold, fatigue, but also may be osteoarthritis, lower extremity deep vein thrombosis and other pathological factors. 1. Physiological factors: due to cold legs, or running for a long time and other factors, can lead to leg muscle tension, spasm, after a large number of sports in the body can produce a large number of metabolites, lactic acid buildup, can cause leg muscle pain, can be relieved after sufficient rest. 2. Osteoarthritis: due to obesity, trauma, joint deformity and other factors can be caused by degenerative joint cartilage or cartilage reactive hyperplasia, triggered by osteoarthritis, knee pain, stiffness, etc., which can lead to aggravation of leg pain at night can affect sleep. 3. Lower extremity deep vein thrombosis: Lower extremity deep vein thrombosis refers to the abnormal clotting of blood in the veins of the lower extremities, blocking the blood vessels and producing aseptic inflammation. It can cause pain, swelling and abnormal sensation in the affected limbs, and when the pain is severe at night, it can cause the patient to be unable to sleep. Leg pain at night can be caused by a variety of other reasons, it is recommended to improve the lower extremity vascular ultrasound, CT, MRI and other examinations, to clarify the cause of the disease for targeted treatment.