The pineal gland is generally located on top of the mesencephalon, above the tegmentum, and on top of the triventricular space, also known clinically as the supracerebral gland. The pineal gland is connected to the three ventricles by a thin stalk, while the three ventricles tend to form the pineal crypt. The surface of the pineal gland is often covered with a continuous connective tissue from the soft meninges that penetrates deep into the parenchyma of the pineal gland, dividing it into irregular lobules. Clinically the pineal lobules are often composed of cells, glial cells and nerve fibers, for which the pineal gland is richer in blood supplying blood vessels, while the pineal nerves are derived from peripheral nerve fibers, including sympathetic and parasympathetic nerves.