Another name for Bactrim is mupirocin ointment, which can usually be used when anal papillomas are combined with an infection, but if the anal papilloma is more severe, surgical treatment may be necessary. Mupirocin ointment is a topical antibiotic medication that has a strong antibacterial effect against a variety of Gram-positive cocci, and some effect against certain drug-resistant Staphylococcus aureus and Gram-negative bacteria. The cause of anal papilloma is usually inflammatory stimulation, local injury and so on, usually combined with infection, this time with mupirocin ointment can have anti-inflammatory effect to some extent. However, if the anal papilloma does not cause local infection, generally do not need antibacterial treatment, and should keep the perianal clean, anal bath after stool, available saline or 1:5000 potassium permanganate solution sitz bath. If the anal papilloma is large, causing more obvious symptoms, often bleeding after bowel movement, incomplete bowel movement, or even ulceration at the anus and other symptoms, surgical treatment may be needed. Patients with anal papilloma are advised to go to the hospital and choose the right treatment under the guidance of specialized doctors to avoid any delay in their condition.