Large cell neuroendocrine carcinoma in lung is serious and belongs to poorly differentiated lung malignant tumor. In early stage, large cell neuroendocrine carcinoma of lung may have symptoms such as coughing, coughing up sputum, hemoptysis, chest pain, etc. It may also compress the recurrent laryngeal nerve and have symptoms such as hoarseness and difficulty in vocalizing, etc. Cure can be achieved through radical surgery and postoperative adjuvant chemotherapy, and it will have less impact on the life if it does not recur for a long period of time. Late stage lung large cell neuroendocrine carcinoma with higher malignant degree may have symptoms such as brain metastasis and meningeal metastasis. If the effect of surgical treatment is not good, systemic treatment can be carried out, and different treatments should be chosen according to the sensitivity and tolerance of different patients, and the commonly used chemotherapeutic drugs are cisplatin and etoposide. Therefore, it is necessary to have regular checkups in daily life, and once large cell neuroendocrine carcinoma is found in the lungs, one should go to the hospital immediately to cooperate with the treatment, so as to achieve early detection and early treatment.