According to the 2012 Zhejiang People’s Health Blue Book released by Zhejiang Center for Disease Control and Prevention on July 2, the incidence and mortality rate of breast cancer among women in Zhejiang has increased significantly in the past few years. And clinically, breast cancer is also one of the cancers with a clear familial tendency. It is recommended that women who have had breast cancer in their family should have a genetic test to detect not only breast cancer but also ovarian cancer at an early stage, which is meaningful to the whole family. Three sisters successively suffered from breast cancer Auntie Li, a native of Hangzhou, is in her 50s. Her two sisters successively suffered from breast cancer a few years ago, so she is very concerned about her health condition and insists on annual medical checkup. She was concerned about her health condition and insisted on annual medical checkups. The results were good for several years, but this year she was “hit” and the medical checkup report indicated that she had multiple lumps in her left breast. Auntie Li found Dr. Fu Peifen with the medical report. She said that her lumps were different from her two sisters and could not be felt at all, so she thought they were benign and not breast cancer. However, combining the medical history and examination results, Dr. Fu highly suspected that she was suffering from breast cancer and suggested her to have a biopsy. The biopsy results confirmed Dr. Fu’s judgment. Auntie Li had three lumps in her left and right breasts, all around 1 cm in size, two of which were diagnosed as cancer, and the location of these two lumps was very hidden, so a slight negligence during the examination might have missed the diagnosis. Since they were multiple, Auntie Li ended up having a total left breast excision. For those who have a family history of breast cancer, it is best to have a genetic test to see if they carry the breast cancer susceptibility genes BRCA1 and BRCA2. If mutations occur, they can greatly increase the risk of breast and ovarian cancer in carriers. Probabilistically, women who carry the mutated BRCA1 gene have about a 60% risk of developing breast cancer, which is five times higher than that of normal women (about 12% for normal women). Some time ago, American actress Angelina Jolie was tested and found to be carrying the BRCA1 gene and had a double mastectomy immediately. Dr. Fu Pei Fen said, “Double mastectomy is undoubtedly an effective way to reduce risk, but it is also one of the most radical methods. In fact, there are quite a few ways to reduce the risk and still retain your beauty.” Dr. Fu said that if the BRCA1 gene mutation is detected, then first of all, breast cancer screening can be done early, starting with annual breast cancer imaging screenings, such as breast ultrasound, mammogram and MRI, from the age of 25-30 to detect earlier breast cancer. A significant percentage of early stage patients are able to keep their breasts and get long-term survival. Secondly, prevention can also be done through medications such as taking tamoxifen, which is recognized worldwide as a drug to reduce the risk of breast cancer, both as a preventive drug for women at high risk of developing the disease and as a treatment for breast cancer patients. Studies have shown that taking tamoxifen orally for 5 years can effectively reduce the risk of breast cancer by 49%, and for women with a history of atypical breast hyperplasia, it can even reduce the risk of breast cancer by 86%.