According to their mechanism of action, they can be divided into three categories: 1. Selective estrogen receptor modulators (SERMs) – compete with estrogen for hormone receptors: tamoxifen (triamcinolone, TAM), toremifene (phalloidin), fulvestrant 2. -Reduces estrogen concentrations in the body: reversible non-steroidal: amiloride (first generation); letrozole (Flon), anastrozole (Renintex) (third generation) irreversible steroids: formestane (Lantalum) (second generation); exemestane (third generation) 3. Ovarian depot: LH-RH analogs – -Reduces estrogen concentrations in the body: Goserelin acetate (Norelide), leuprolide acetate (Inhibiton) Also included: Progestins Medroxyprogesterone (MA) Mestanolone (mestanolone)