Due to the decline of ovarian function and the decrease of estrogen secretion in the body, some women may experience “menopause syndrome”, such as menstrual disorders, irritability, mental fatigue, dizziness and tinnitus, palpitations and insomnia, baking and sweating, etc. In severe cases, personality changes and mild mental disorders may occur. Menopause is a period of transition from prime to old age, a special period of physiological change, and should be fully prepared physically and mentally. In recent years, it has become more popular abroad to take hormone replacement agents during menopause to alleviate the manifestations of menopausal syndrome, and some people in China have also started to use hormone replacement agents. Whether menopausal women should take hormone replacement agents is a controversial issue. Some scholars believe that taking hormone replacement agents can supplement the deficiency of endogenous hormones in menopausal women, effectively alleviate the various symptoms of menopausal syndrome, and prevent coronary heart disease and osteoporosis that occur in women after menopause due to the sharp decrease in estrogen secretion. Therefore, it should be said that taking hormone replacement agents is beneficial to women in menopause. However, the issue of whether taking hormone replacement agents can lead to breast cancer has attracted more and more attention from scholars at home and abroad in recent years. The latest foreign studies suggest that taking hormone replacement agents can increase the risk of breast cancer in women, and this risk may persist; the longer the duration of taking hormone replacement agents, the higher the risk of developing breast cancer. For breast cancer patients, the use of hormone replacement therapy after surgery may also make the cancer more likely to recur. Therefore, we believe that hormone replacement agents should be taken with caution by menopausal women. If there is no obvious manifestation of menopausal syndrome or only a mild degree of discomfort, they can use other methods instead of hormone replacement, such as actively exercising and participating in various social activities to maintain a good state of mind and physical condition. For those who do have obvious symptoms, they can take Chinese herbal medicine, or take hormone replacement agents in small amounts and for a short period of time under the guidance of a doctor. And for breast cancer patients, it is recommended to avoid hormone replacement therapy as much as possible.