If the high fever is caused by taking targeted drugs, you can use drugs to lower the temperature, physical cooling. In addition, patients should adjust the dosage or stop the drug under the guidance of the doctor. If the adverse reaction of high fever occurs when taking targeted drugs, you can use acetaminophen, ibuprofen and other antipyretic drugs under the guidance of the doctor, and some patients can also take physical cooling to reduce the body temperature, such as warm water baths, applying fever-reducing patches, or using a towel wrapped with ice cubes in the armpits, groin, popliteal fossa and other locations to apply ice packs. In addition, patients should usually drink more water, which can avoid the accumulation of drugs in the body. Patients with high fever should also adjust the dosage of targeted drugs or replace targeted drugs under the guidance of the doctor, and most patients with high fever will get better after stopping targeted drugs. In addition, patients taking targeted drugs with high fever may also be caused by infections or tumors and other diseases. It is recommended that patients taking targeted drugs with high fever symptoms need to consult a doctor in a timely manner to clarify the cause of the disease and choose the appropriate treatment according to the cause.