Chronic seminal vesicle inflammation can be treated with quinolone antibiotics such as levofloxacin tablets; large chronic seminal vesicle inflammation can be treated with quinolone antibiotics such as levofloxacin tablets; macrolide antibiotics such as azithromycin; or cephalosporin antibiotics such as cefixime dispersible tablets. You need to choose the right antibiotic according to the pathogen, there is no such thing as the best. Patients with chronic vesiculitis often have a long history of the disease, no matter which antibiotics are used for treatment, they need to be used in sufficient quantities and courses. It is best to do semen culture and drug sensitivity tests, according to the results of the selection of sensitive antibiotics, continuous use of drugs for more than 3 weeks, can not just stop or reduce the amount of drugs. During the treatment period, you need to pay attention to a lighter diet, can not eat spicy and stimulating food, can not drink alcohol, need to suspend sexual intercourse. Some patients may have allergies, nausea, vomiting and other uncomfortable symptoms after using the drug, need to be under the guidance of a professional doctor for regular use, can not blindly use the drug on their own.