Pulmonary nodules are less likely to be tuberculosis. Mycobacterium tuberculosis infection is suggested by nodular changes on chest radiographs or lung CT. When a patient’s lung CT suggests a nodule in the lung, the nature of the nodule should be further evaluated in conjunction with the patient’s other clinical symptoms. If the patient has small nodules with smooth margins and a small number of nodules, they are clinically considered to be benign nodules and do not require drug treatment, only regular review. If the patient has large nodules with unsmooth margins and burr signs, and if the patient develops symptoms such as fever, chest pain, coughing up blood and weight loss, the nodules are clinically considered to be malignant, and bronchoscopy, puncture biopsy and other related tests are needed to clarify the diagnosis. If the patient has symptoms such as low fever, weakness, night sweats and wasting, the nodules caused by pulmonary tuberculosis cannot be excluded clinically, and it is necessary to improve PPD test, blood sedimentation, sputum check for antacid bacilli and other related tests.