Adverse reactions occur and should be discontinued promptly. The most common is allergic reaction, mild patients will appear rash, swelling, or itching, breathing restrictions, serious cases can affect the circulatory dynamics, and hypotension, shock, or even life-threatening, so the drug should be promptly discontinued. In addition, there are chronic adverse reactions will appear renal insufficiency, hepatic insufficiency, need to take into account the laboratory results and the needs of the disease, reduce the dose or discontinue the drug. And also during the treatment period, it is important to observe the change of symptoms and signs. There are many adverse drug reactions that can be easily detected, and those that can be controlled should be used under the monitoring of effective blood levels, and those that are serious should be stopped in time. During the medication period should also pay attention to drink more water, because it can promote the production and excretion of urine, to a certain extent, can also accelerate the metabolism of drugs.