Abnormalities of chromosome 22 in newborns may lead to congenital disorders, neuropsychiatric disorders, immune deficiency, and increased incidence of tumors. 1. Congenital diseases: deletion of genes in specific regions of chromosome 22 may lead to palatocardiofacial syndrome, birth defects, congenital heart disease, mental retardation, and so on. 2. Neuropsychiatric disorders: amyotrophic lateral sclerosis, schizophrenia, etc. 3. Low immunity: in all stages of growth, it is easy to complicate various infections, such as pneumonia, meningitis, etc. 4. Increased incidence of tumors: increased incidence of leukemia, breast cancer, type 2 neurofibromatosis and various malignant tumors. If the examination finds that chromosome 22 is abnormal, further examination should be carried out in time.