Treatment of atherosclerosis of the lower extremities is categorized into non-surgical and surgical approaches. Non-surgical methods include general treatments such as controlling underlying diseases and smoking cessation, as well as drug therapies including beziridine sodium, aspirin, simvastatin, and so on. Surgical treatment can be considered when medication is ineffective and seriously affects life. 1. Non-surgical: reduce blood pressure and blood lipids, control diabetes, improve blood hypercoagulability and promote the formation of collateral circulation. It is also necessary to quit smoking, carry out appropriate foot exercises, keep warm and avoid injury. For patients in the middle and early stages or those who cannot tolerate surgery, vasodilators such as cilostazol and beclomethasone sodium, antiplatelet aggregation drugs such as aspirin and clopidogrel, and lipid-lowering drugs such as simvastatin and atorvastatin can be used. 2. Surgery: Surgery is feasible for rest pain, intermittent claudication, and lower extremity ulcers or gangrene that severely affect quality of life. Including percutaneous endoluminal angioplasty, arterial bypass surgery, thrombus endarterectomy, venous arterialization and so on. In summary, patients with lower limb atherosclerosis must be treated with medication according to the doctor’s instructions, and life care must be strengthened to prevent aggravation of the condition.