Trypanosoma cruzi is an African human trypanosomiasis, also known as sleeping sickness, which is a vector-borne parasitic disease. Trypanosoma brucei and Trypanosoma brucei Rhodesia are the causative agents of African trypanosomiasis or African trypanosomiasis, and the vector insects are tsetse flies. Trypanosoma gambiae is found along rivers or along forests in West and Central Africa, while Trypanosoma rhodesiae is found in shrub and vegetation zones in the savannas and lakeshores of East Africa. Africantrypanosomiasis (Africansleepingsickness) has three clinical stages, the first of which is the invasion of the skin, causing varying degrees of hardness and nodules, which evolve into trypanosomatous chancre, which occurs in about one-third of patients and is often found on the exposed skin where the tsetsefly bites. The chancre occurs in about one-third of patients and is often found on the exposed skin where the tsetsefly bites and lasts for about 3 weeks. The second period is the hemolymph period, when symptoms such as periodic fever and parasitemia occur, including lethargy, swelling of lymph nodes in the back of the neck, joint pain, headache, and red rash on the trunk, and myocarditis, and jaundice due to hemolysis and liver damage. Once the brain is invaded, it will enter the third stage of meningoencephalitis, when headache, insomnia, movement disorders and behavioral disorders occur, and other symptoms include general weakness, dramatic loss of appetite and body wasting. The basic processes of the two species of trypanosomes after they invade the human body include: the initial reaction phase and the hemolymph phase, as well as the meningitis phase, which invades the central nervous system. Initial reaction stage: About 1 week after the patient is bitten by tsetse fly, the local skin is swollen and a red spot appears in the center, which is the trypanosome chancre. Hemolymphatic phase: Trypanosoma cruzi enters the blood and intertissue lymphatic fluid, causing extensive lymph node enlargement. The peak of trypanosomiasis can last for 2-3 days, accompanied by fever, headache, arthralgia and limb pain. At this stage, generalized lymph node enlargement may occur, especially in the posterior neck, submandibular and inguinal areas. The swollen lymph nodes in the posterior cervical triangle (Winterbottom’s sign) are characteristic of Trypanosoma gambiae. Meningoencephalitis stage: It commonly becomes diffuse molluscum contagiosum with cerebral cortical congestion and edema, neuronal degeneration, and glial cell proliferation. The main clinical symptoms are personality changes and anaphylactic state. Abnormal reflexes, such as deep sensory hypersensitivity, ataxia, tremor, spasticity, lethargy, and lethargy, are present. Trypanosomiasis of The Gambia has a chronic course, which can last from several months to several years, with mild symptoms and central nervous system abnormalities. Rhodesian trypanosomiasis has an acute course with a duration of 3-9 months. Patients tend to present with significant wasting, hyperthermia and failure. Some patients die before the central nervous system is invaded.