The common causes of high creatine kinase are: a lot of strenuous exercise, myocarditis or myocardial disease, acute myocardial infarction, rhabdomyolysis, in which the elevation of creatine kinase caused by exercise belongs to the physiological causes. 1. A lot of strenuous exercise, creatine kinase is widely present in the cell plasma and mitochondria of human muscle tissues, when strenuous exercise, due to insufficient supply of energy and other reasons leading to an increase in the permeability of myocytes, causing the release of creatine kinase. 2. Myocarditis or myocardial disease, myocardial cells contain a large amount of creatine kinase, when suffering from myocarditis, it will lead to increased concentration of creatine kinase in the body. 3. Acute myocardial infarction, in which elevated creatine kinase usually occurs within 3 to 8 hours of onset. The presence of elevated creatine kinase should be promptly consulted to clarify the specific causes and follow the doctor’s instructions for treatment. 4, rhabdomyolysis, some statin drugs (such as atorvastatin), trauma, etc. will cause rhabdomyolysis, release creatine kinase, resulting in creatine kinase elevation. There are many reasons for elevated creatine kinase, and patients are advised to actively seek medical advice for differential diagnosis and treatment.