Xenadrine, also known as progesterone vaginal extended-release ketone gel, can be used after lying down for 5 to 10 minutes after use, but it is not absolutely required. Progesterone Vaginal Extended Release Ketone Gel needs to be inserted into a woman’s vagina, and after inserting the drug you can lie down for 5 to 10 minutes afterward, but it is not absolutely required in order to prevent dislodging and speed up the rate of absorption in the body. Then you can come down and walk around for about half an hour, which is conducive to drug absorption. By walking around the drug residue can naturally flow out, half an hour after the drug will start to absorb the drug, will continue for about 24 hours time. Xenadrine is a vaginal medication and should not be taken orally. Adverse reactions such as constipation, nausea, fatigue, headache, vaginal itching, and changes in skin pigmentation may occur during administration. After a few days of using the drug, tiny white globules may appear in the vaginal discharge, which is a common phenomenon and you can consult your doctor. Patients using Xenadrine medication should be under the guidance of a professional doctor.