Alcohol is a beverage in daily life and is likely to be shared with other drugs, so it is necessary to pay attention to the interaction between ethanol and other drugs. First, antipyretic and analgesic drugs Commonly used antipyretic and analgesic drugs include: aspirin, ibuprofen, acetaminophen, diclofenac, indomethacin, aminopyralid, and its compound preparations of painkillers, flu flu flu, Benzene tablets, white plus black, aminophenol huangnamin, etc.. Both antipyretic and ethanol can damage the gastrointestinal mucosa, and if you drink a lot of alcohol after taking antipyretic and analgesic drugs, it can cause the gastrointestinal mucosa to be doubly stimulated by drugs and ethanol, and even cause peptic ulcers or bleeding. Acetaminophen is less irritating to the gastrointestinal tract, but its metabolites have a certain degree of hepatotoxicity. Ethanol can induce hepatic drug enzyme CYP2E1), increase the production of toxic metabolites of acetaminophen, enhance the hepatotoxicity of acetaminophen. Second, antibacterial drugs Cephalosporins such as cefoperazone, cephalosporin, cefmetazole, cefamandole, cefmenoxime, cefotiam, and metronidazole, tinidazole, furazolidone and so on can cause disulfiram-like reaction. Disulfiram-like reaction, manifested as the use of alcohol after the drug appeared limb weakness, weakness, drowsiness, vertigo, hallucinations, headache, nausea, vomiting, chest tightness, generalized flushing, defecation, convulsions, and even a drop in blood pressure, respiratory depression, shock and other reactions. Mild cases can be relieved on their own, while severe cases should take necessary measures in time for rescue. Therefore, patients should be prohibited from drinking alcohol 2 days before using the above drugs, and avoid drinking alcohol and taking ethanol-containing beverages and medicines for 1 week after using the drugs. Third, hypoglycemic drugs, methylbenzenesulfonylurea, chlorosulfopropylurea can inhibit the metabolism of ethanol, causing disulfiram-like reaction, should be avoided with ethanol. In addition, ethanol and metformin and other oral hypoglycemic drugs and insulin, can cause dizziness, panic, cold sweat, hand shaking and other hypoglycemic reactions, severe hypoglycemic coma can occur. Fourth, anti-angina drugs nitrate drugs anti-angina drugs (nitroglycerin, isosorbide nitrate, etc.) through the expansion of coronary arteries and small blood vessels throughout the body, reduce the anterior and posterior load on the heart and improve myocardial blood supply, alleviate angina pectoris to correct heart failure. Drinking alcohol during the use of drugs can lead to a significant expansion of small blood vessels, blood pressure drop, dizziness, weakness, etc., the heavy cardiovascular collapse, at this time the myocardial blood supply is further reduced, more likely to exacerbate angina pectoris or induced myocardial infarction. Fifth, antihypertensive drugs Research shows that drinking more than 30g of alcohol per day can make diastolic and systolic blood pressure rise 1.5~2.4mmHg; blood pressure measurement within 24 hours after drinking, diastolic and systolic blood pressure rise the most. Reducing or stopping alcohol consumption in alcoholics may reduce the dosage of hypertension medication or bring blood pressure down to within the normal range. In addition, ethanol has a certain vasodilating effect, and nifedipine, cloxartan, hydralazine, diprazole and other antihypertensive drugs taken together, it is easy to appear postural hypotension. Diuretics Ethanol and its metabolite acetaldehyde have vasodilatory effects, which can enhance the efficacy of vasodilators. Especially when applying thiazides and other diuretic antihypertensive drugs, if drinking alcohol, can aggravate postural hypotension. Drinking red people metabolize acetaldehyde ability is poor, more likely to be dangerous, so take these drugs should avoid drinking. Cimetidine Cimetidine can increase the concentration of ethanol in the blood and increase the degree of intoxication. Double-blind study proved that if you take cimetidine for 7 days and then drink alcohol, the concentration of ethanol in the blood will increase by 12%, the AUC will increase by 7%, and the patients will be easily intoxicated. Eight, anti-allergic drugs Ethanol can enhance the central inhibitory effect of first-generation antihistamines (chlorpheniramine, cycloheximide, phenylephrine, etc.), which can cause drowsiness, trance, coma, and should be avoided with the same dose. Although in therapeutic doses, the second generation of antihistamines (cetirizine, loratadine, etc.) of the central inhibitory effect is weaker, will not strengthen the role of ethanol, but should also be avoided after taking alcohol. Nine, sedative-hypnotic drugs taking sedative-hypnotic drugs at the same time a large number of alcohol, can significantly aggravate the central nervous system inhibition. It can cause drowsiness, trance, coma, respiratory failure, and even death. Therefore, taking sedative-hypnotic drugs, including diazepam, nitrazepam, clonazepam, flunitrazepam, triazolam and so on, prohibit the consumption of alcohol. Ten, antipsychotics Phenothiazines, such as chlorpromazine, isopromazine, etc. can slow down the metabolism of ethanol decomposition, aggravate nausea, vomiting, headache, flushing and other symptoms of intoxication; alcohol consumption can aggravate the adverse effects of chlorpromazine and other hypertensive reactions, and aggravate the central inhibitory effect of chlorpromethorphan. Eleven, antiepileptic drugs with phenytoin treatment of epilepsy and peripheral neuralgia patients drinking alcohol, even if the routine drug, will induce seizures, this is ethanol through the enzyme-induced acceleration of drug metabolism results. XII, narcotic drugs morphine, codeine and ethanol combined, the central inhibitory effect is strengthened, can cause respiratory function weakening, should be avoided. Thirteen, monoamine oxidase inhibitors The use of monoamine oxidase inhibitors, eugenol, dysentery, phenelzine, methylbenzylhydrazine, mulled cola, ethanol can enhance the role of nausea, vomiting, abdominal pain, diarrhea, headache, dizziness, respiratory distress, dyskinesia, the serious can cause convulsions, arrhythmia, myocardial infarction, coma and so on. This is because the monoamine oxidase in the heart, liver and brain tissue is inhibited, so that neurotransmitters such as norepinephrine are not easily destroyed, so that the content is too large, increasing the body’s sensitivity to alcohol. The inhibition of monoamine oxidase by these drugs is irreversible, and the monoamine oxidase in the body can be restored to normal only after stopping the drugs for two weeks, therefore, not only should not drink alcohol during the period of taking the drugs, but also should not drink alcohol within two weeks after stopping the drugs. Vitamin drugs Ethanol can directly damage the mucous membrane of stomach and small intestine. Long-term alcohol consumption can reduce the absorption of folic acid and B vitamins; for patients with these vitamin deficiencies, it is undoubtedly adding to the problem and aggravating the condition. Ethanol and ethanol dehydrogenase have a strong affinity and can compete to inhibit the conversion of vitamin A to retinaldehyde, so that the prevention and treatment of night blindness by vitamin A is reduced. Long-term alcohol consumption can cause renal tubular hypoplasia, renal production of α-hydroxylase insufficiency, 1,25-(OH)2-D3 synthesis is reduced, affecting intestinal calcium absorption, resulting in hypocalcemia.