The cause of the formation of rheumatic diseases is not known and may be due to infectious factors, genetic factors, autoimmune diseases and other uncertain factors. The cause of the formation of rheumatic diseases is still unknown and may be related to group A beta-hemolytic streptococcal infections. In addition rheumatic diseases such as ankylosing spondylitis, rheumatoid arthritis, and systemic lupus erythematosus have a genetic susceptibility. If the patient has a family history of these diseases the probability of developing rheumatism is higher than the general population. In addition, the patient’s immune cell function is altered, which will lead to cross-reactivity in the body and easily lead to rheumatic diseases. As the cause of rheumatic disease is still unclear, it is recommended that patients with rheumatic disease should seek timely rheumatology and immunology, and can take targeted measures under the guidance of the doctor for treatment.