The blisters on the top of the lips may be caused by inadvertent bites or food contusion mucus gland cysts, which generally require surgical excision treatment and need to be removed surgically at the stomatology clinic, and the stitches should be removed in about 7 days, and after the stitches are removed, you should not eat spicy and irritating food to avoid infection, and oral anti-inflammatory drugs such as amoxicillin or roxithromycin are recommended. At the same time, clusters of small blisters on the surface of the lips may be caused by the herpes simplex virus, which generally requires antiviral treatment, with the conventional use of drugs such as acyclovir, valacyclovir or ribavirin. It is recommended to improve the body’s resistance to avoid long-term recurring attacks due to low immunity, and to apply local acyclovir ointment, which can promote rapid healing of the blisters.