Alfacalcitol is one of the most commonly used medications for the treatment of osteoporosis as well as for the improvement of diseases with abnormal vitamin D metabolism, and is generally effective when used correctly. Alfacalcitol improves osteoporosis in hormone-using or postmenopausal women by regulating calcium and phosphorus metabolism and increasing calcium absorption. It can relieve symptoms of low back pain, bone pain, and weakness. Alfacalcitol can also treat diseases caused by vitamin D metabolism disorders, such as rickets, achondroplasia, renal bone disease and so on. Correct use can achieve good therapeutic effect. Alfacalcitol can cause stomach pain, elevated aminotransferases, elevated blood pressure, and headache if overdosed during use. Regular review of blood calcium and urea nitrogen is needed. For hypercalcemia and vitamin D allergy can not be used, pregnant women can not be used. Alfacalcitol needs to be used under the guidance of a doctor, if discomfort occurs during use, you need to stop the drug in time and seek medical attention.