One of the symptoms of malaria infection is that Plasmodium can be found in blood, bone marrow or sputum smears. Blood marrow or sputum smear to find Plasmodium is a method to check the disease. In the epidemic period of such disease, Plasmodium is more acute, with high fever and chills, coma and convulsions. The sudden high fever, chills and coma in infants and children in the epidemic area have a lot of impact on the health of the body and should be examined and treated in a timely manner to prevent the occurrence of other internal diseases. Diagnostic points for finding Plasmodium in blood marrow or sputum smear: (1) Most cases have chills or chills of varying duration before the fever. (2) The body temperature rises rapidly in a short period of time, lasts for several hours, and then falls quickly, followed by sweating of varying degrees. If the body temperature is measured every 2-4 hours and the temperature curve is analyzed, it is found that the body temperature at night often drops to normal or below normal temperature. (3) The seizures are timed, and the febrile and fever-free periods occur alternately with some regularity. (4) Patients generally feel well during the interictal period except for fatigue, weakness and slight discomfort. (5) The onset of the attack is mostly seen around noon and in the afternoon, and the onset of the attack at night is less frequent. (6) The clinical symptoms are more severe than once, and after several episodes, they gradually decrease, with a tendency of “self-healing”. (7) Clinical manifestations of hemolytic anemia, the degree of which corresponds to the number of episodes. (8) Splenomegaly, the extent of which is related to the course of the disease, and in some cases, hepatomegaly. (9) Clinical symptoms are often atypical in infants and young children, in falciparum malaria, and in the first one or two episodes of new infections. In addition, some patients with high immunity have a large number of protozoa in their blood, but clinical symptoms are not obvious or completely absent, especially with reference to physical examination and laboratory tests to determine the diagnosis. The diagnosis can be confirmed if Plasmodium can be found in the peripheral blood during laboratory tests.