The etiologic mechanism of oral leukoplakia is unknown, and it is generally difficult to cure. 1. Oral leukoplakia is a kind of oral mucosal disease, the etiologic mechanism is not very clear, may be related to tobacco and alcohol stimulation, too hot food stimulation, or the body of micronutrient deficiencies, etc., most commonly seen in middle-aged men and above. 2. White plaques appear on the oral mucosa, can not be wiped away, clinically manifested as hyperplasia, warts, granular, self-sense of roughness and discomfort. 3. usually try to minimize the stimulation, in the treatment can be used in vitamin A cream, cod liver oil and other drugs local external coating. You can also use laser, electrotherapy, freezing and other treatments, ulcers, pain or cancerous tendency, can consider surgical excision. As the cause of white spots is unknown, so it is difficult to cure clinically, we need to regular follow-up, standardized treatment under the guidance of the doctor, the use of drugs need to follow the doctor’s instructions.