EBV IgA positivity is generally of little clinical significance, and its harm needs to be determined in conjunction with IgM and IgG antibodies. EBV is a human herpesvirus. Positive EBV IgA antibody is clinically indicative of a previous or ongoing EBV infection and is generally of little significance. If EBV antibodies are positive, further testing is needed to clarify whether IgG antibodies are positive or IgM antibodies are positive. If the IgG antibodies are positive, it means that the patient has been infected with EBV, and if the IgM antibodies are positive, it indicates that the patient may have been recently infected, and if there are no physical abnormalities, no treatment is needed. If the patient is a child and is accompanied by fever, nausea, vomiting and diarrhea, this may impair liver function and complicate infectious mononucleosis, and intervention is necessary. EBV infection and nasopharyngeal cancer have a certain relationship and require high attention in EBV testing, but the harm to the human body can also be reduced through prevention, early detection and early treatment. Patients are advised to keep a good state of mind and not to be overly panicked or anxious as a result. Seek timely medical treatment for a clear diagnosis, and follow the doctor’s instructions for treatment and review.