For perimenopausal women, if the thickness of the endothelium is 1.5cm, it is considered to be relatively thick, due to the ovarian function has been reduced to varying degrees, so the patient will have irregular ovulation, which will lead to the endothelium can not be completely stripped off, and at this time, it can be treated through medication, surgery and other ways of treatment. 1. Medication: Since there is still a certain level of estrogen in the patient’s body, progesterone, progesterone and other progestin preparations can be taken as prescribed by the doctor to make the endothelium undergo a secretory phase reaction and then be completely stripped off. 2. Surgical treatment: For perimenopausal women, if the endometrium is thick, we should be alert to the occurrence of endometrial polyps and endometrial cancer, so if necessary, we need to follow the doctor’s instructions to perform cervical scraping and send the pathologic examination to clarify the type of disease. For perimenopausal women who are found to have a 1.5cm thick endometrium, it is recommended that they go to the gynecology department of a regular hospital for active treatment under the guidance of a doctor.