Thickened toenails need to be treated with medication and surgery according to the cause of the disease, and common diseases include onychomycosis, thick nails and so on. 1. Onychomycosis: Onychomycosis is a nail lesion caused by fungal infection that invades the nail plate and nail bed, which manifests itself as cloudy, thickened, brittle, discolored, and shedding of the nail plate, etc. It can be treated with local topical amorphophallus application, and at the same time, combined with the application of oral medications, such as terbinafine hydrochloride tablets and itraconazole capsules, etc. When there are relevant indications, it can be treated with nail extraction or nail removal surgery. 2. Thick Nail Disorder: Thick Nail Disorder is mainly related to heredity, manifesting as hypertrophy of fingernails and toenails, hyperkeratosis of palm and plantar surface, excessive sweating, etc. It can be treated with onychomatous nevus and scraping of nail bed, and if accompanied by keratotic lesions, it can be treated with topical salicylic acid cream, urea cream, etc. If accompanied by keratotic papules and mucous membrane leukoplakia, it can be treated with oral isotretinoin. All of the above drugs should be used under the guidance of a professional doctor, avoid self-medication. Thickening of the toenails may also have other causes, it is recommended to go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease and then give targeted treatment.