Enlarged lymph nodes in the neck are mostly caused by infection, tuberculosis, tumor and so on, and should be treated according to the specific cause and choose the appropriate treatment. The lymphatic drainage of the head and neck is rich, so there are many lymph nodes in the neck, and some pathological factors can cause enlargement of the lymph nodes in the neck. If it is caused by infection, antibiotic treatment or clinical follow-up is needed. Most of the enlarged lymph nodes will subside after the inflammation subsides, and some of the enlarged lymph nodes will exist for a long time, but as long as the blood test returns to normal and there are no symptoms, then there is no need to continue the treatment. In case of lymph node tuberculosis, regular anti-tuberculosis treatment is required, often combined with isoniazid, rifampicin, ethambutol and other drugs. If the lymph node enlargement is caused by a tumor, the primary tumor must be treated to be effective. After neck CT detects enlarged lymph nodes in the neck, further examination should be carried out in a timely manner to make a clear diagnosis, and then follow the doctor’s instructions to be treated accordingly.