Blisters on the palm of the hand, may be due to local friction, sweat herpes, hand, foot and mouth disease or ringworm and other causes. 1. Physiological factors: long-term friction in the palm area can cause local subcutaneous oozing, forming blisters, often painful, generally self-absorbing. 2. Sweat herpes: belongs to the hand eczema special type, can appear in the palm and toe, lesions are deep in the blisters, containing pulp and can be fused into a large blister, often conscious itching or burning sensation. 3. Hand, foot and mouth disease: often caused by coxsackie virus, can be transmitted by fecal-oral route, droplet transmission through the respiratory tract, the appearance of hands, feet, oral red rash, quickly developed into blisters, blisters, blisters, thin wall, blister liquid clear, after the formation of vesicles or shallow ulcers. 4. ringworm: there are superficial fungal infections, such as blister type, can occur in the interphalangeal, palm and other places, lesions at first deep in the blisters, the blister wall is thick and not easy to rupture, after absorption there will be flaking, often with obvious itching. Blisters on the palm of the hand, itching, flaking or other symptoms suggest timely medical advice, according to the characteristics of the lesions and lesion characteristics to determine the cause of the disease, and comply with the doctor’s instructions for treatment.