At present, in the outpatient clinic often encounter some liver disease patients, in a large number of drugs, a wide variety of Chinese and Western herbal medicines are available, these drugs, the recovery of liver disease is not much benefit, on the contrary, is likely to increase the burden on the liver, damage the metabolism of the liver, while bringing a considerable economic burden to patients. The following are some commonly used drugs, but in the use of the liver may bring certain effects, hope that patients with liver disease in the application of attention. Precautions for patients with liver disease: 1, sulfonamides, para-aminosalicylic acid, finasteride, iodine-containing contrast agents, neomycin, protein all-forming hormones and contraceptives, to some extent, cause disorders of bilirubin metabolism, causing jaundice and elevated transaminases. 2, paracetamol, schistosomiasis treatment drugs, deworming nitrothiocyanine, treatment of chronic hepatitis 6-mercaptopurine, azathioprine and glutamycin, mitomycin, self-limitomycin, contraindomycin, actinomycin and other antitumor drugs, Antoine, a large number of niacin and other lipid-lowering drugs, the treatment of skin disease aminopterin and Chinese medicine tumble pills can cause hepatocyte necrosis due to large doses and even small doses can cause metabolic reaction And the occurrence of elevated transaminases, jaundice, there are also reports of death. 3, rifampin and isoniazid are commonly used effective anti-tuberculosis drugs, but often cause allergic hepatitis and cholestasis; treatment of diabetes methanesulfonylurea (D860), very easy to cause liver damage. Phenazine can cause severe hepatic necrosis; chlorpromazine, promazine, prochlorperazine, trifluoperazine, etc. can cause cholestatic jaundice. Erythromycin propionate causes jaundice, static tetracycline causes hepatic necrosis, and jaundice due to triacetin has been reported in many cases. 4, the abuse of altered hemodynamic vasoconstrictors and antihypertensives, general anesthetics and some sedative sleeping drugs, as well as nerve blocking drugs, long-term use of blood circulation dysfunction of the liver may cause metabolic dysfunction, resulting in delayed liver function disorders. 5, in part of acute hepatitis and chronic active hepatitis, a large number of long-term application of corticosteroids, can be due to fat metabolism disorders, obesity, immune function suppression and secondary bacterial, mycobacterial infection. Well-fed chronic hepatitis patients, long-term application of large amounts of glucose liquid sedation, can cause fatty liver, resulting in long-term poor liver function. Another example is that patients with severe hepatitis with ascites or little urine, inappropriate application of strong diuretics, often easy to cause a large amount of water electrolyte loss, inducing hepatic coma. This shows that hepatitis patients with too much medication, medication is not reasonable or blind medication, often botched, affecting the condition or even aggravate liver damage. Almost all drugs have to go through the liver metabolism, regardless of Chinese medicine and Western medicine have it can treat one side of the disease, but also has its side effects. There is a lack of research on whether more drugs can cause liver damage, so patients with liver disease should pay attention to the careful and rational selection of drugs under the guidance of a specialist when treating liver disease and its comorbidities or treating co-existing diseases in self-healing.