Stage IV breast cancer is generally defined as advanced breast cancer with a survival period of about four years or more. Stage IV breast cancer is an advanced stage and survival depends on the malignancy of the breast cancer. There are more treatments for breast cancer, if it is triple negative breast cancer stage IV, the treatment program is not very good, because there is no effective treatment program for triple negative breast cancer, there is no endocrine therapy and targeted therapy, and the chances of surviving four years are basically below 50%. If it is ER, PR positive breast cancer, and HER-2 positive breast cancer, with subsequent targeted therapy, the use of CDK4/6 inhibitors, and endocrine therapy, it can be survived for a long period of time, even 6-10 years.