Intractable itchy skin may be due to neurodermatitis, itchy rash, urticaria, pruritus, etc. Different diseases have different causes, and the ointments used may be different, as follows: 1. Neurodermatitis: neurodermatitis, also known as chronic lichen simplex, can choose to use topical glucocorticoid drugs, such as compound dexamethasone cream, etc., but also oral antihistamines and so on. 2. Itchy rash: itchy rash is usually manifested as pimples and nodules, accompanied by intense itching. Topical glucocorticoid drugs can be used to stop itching, such as dieldrin cream, etc., and oral antihistamines can be taken. 3. Urticaria: Urticaria is caused by the temporary increase in the permeability of the blood vessels of the skin and mucous membranes, can be used externally with glycerine lotion, Benadryl cream to relieve itching, but also oral antihistamine. 4. Pruritus: Pruritus generally only itchy feeling, no primary skin lesions. First of all should avoid scratching, external glycerine lotion or compound camphor cream to stop itching, itching severe oral antihistamines. For patients with persistent itchy skin, it is recommended to go to a regular hospital in time, under the guidance of the doctor to choose the drug standardized treatment, do not use their own medication to cause serious adverse reactions.