Pediatric fever enema for the child’s injury, first of all, the impact of the microenvironment in the rectum, the rectum has a fixed physiological environment, if long-term or multiple enemas with drugs, will lead to the rectal mucosa, rectal pH, and rectal wall secretion and absorption function and physiological environment changes, damage to the intestinal tract. Secondly, there are a lot of bacteria in the intestinal tract, it is likely that with the enema liquid into the depths of the intestinal tract, resulting in contamination, especially some antibiotic enema liquid, it is possible to kill the beneficial bacterial flora in the intestinal tract, resulting in the body of the bacterial flora imbalance, secondary infection and diarrhea. Pediatric fever enema harm many, so pediatric fever enema, must pay special attention to comprehensive assessment of the overall condition of the child, to see whether it can be tolerated.