Ultrasound is currently one of the most commonly used imaging methods for gallbladder. This method is fast, accurate, inexpensive and simple, and is currently very widely used in clinical practice. A normal gallbladder wall appears uniform and smooth on ultrasound, and when it is grossly thickened, the most common cause is due to cholecystitis. In this case, the gallbladder is likely to be combined with bile duct stones, which are strong echoes in the gallbladder that can change position with body movement under ultrasound. Patients may have different degrees of right upper abdominal pain at this time, and may also have clinical symptoms such as radiating pain in the right shoulder, fever, nausea, etc., which are relatively easy to determine. However, acute and chronic hepatitis, cirrhosis and other liver lesions may also cause thickening of the gross gallbladder wall, mainly because the gallbladder is located in the gallbladder fossa of the liver, and liver lesions may cause abnormal changes in the shape of the gallbladder, at which time the patient does not have the clinical symptoms caused by the gallbladder, and the degree of thickening of the gallbladder wall is not as obvious as in cholecystitis. In addition, if there is uneven thickening of the gallbladder wall, one should be highly alert to the possibility of gallbladder cancer, and of course, it may also be a polyp-like lesion of the gallbladder such as limited gallbladder adenomyosis.