Urine leukocytes 1 + have physiological factors and pathological factors caused by physiological factors caused by the general need for treatment, pathological factors caused by the need for treatment. 1. Physiological factors: in the examination of urine leukocytes 1 + may be in the process of collecting urine contamination, at this time there is no need for treatment. 2. Pathological factors: urethritis, cystitis and other urinary tract infections will appear in the urine leukocytes 1 +, patients need to drink more water, if necessary, take antibiotic treatment, such as levofloxacin, amoxicillin and so on. Interstitial nephritis patients fluid can appear in the urine leukocytes positive, urine culture negative situation, this time can follow the doctor’s instructions to apply prednisone, cyclophosphamide and other treatments. Urine leukocytes 1 + need to timely regular hospital medical treatment, identify the cause of treatment.