The value of urine creatinine is clinically influenced by the 24-hour urine volume. For example, if the patient’s urine volume increases, the urine creatinine will also appear correspondingly elevated, which need not be too worried. However, if the elevated urine creatinine caused by certain pathological factors should be taken seriously, the possible hazards: First, diabetes, patients with diabetes will have an increased urine creatinine. A series of complications may occur with diabetes, such as diabetic retinopathy, diabetic nephropathy, and atherosclerosis caused by diabetes. Second, a common pathological factor for increased urinary creatinine is hypothyroidism, which may then affect the patient’s growth and intellectual development. Third, infection, patients with infection can lead to increased urine creatinine. If the infection is not effectively controlled, sepsis may even occur as well as the possibility of infectious shock, which is life-threatening. On the contrary, if the urine creatinine decreases, it often indicates renal insufficiency, which should be paid enough attention to.