Low indirect bilirubin may be caused by an error in the test, or by a difference in the test results caused by different instruments and reagents, or by the fact that there are fewer senescent red blood cells and the liver is more capable of processing bilirubin. Generally speaking, low indirect bilirubin has no effect on the human body and there is no need to worry too much. Clinical analysis should pay attention to the emergence of indirect bilirubin elevation, if it is mildly elevated, may not be too big a problem, may be caused by long-term alcohol consumption and excessive obesity. If the indirect bilirubin is significantly elevated, this is mostly indicative of the presence of diseases that may have a more serious impact on the human body. Common diseases include hepatocellular jaundice and hemolytic jaundice. Hemolytic jaundice refers to the phenomenon of hemolysis during blood transfusion due to incompatibility of blood groups, which leads to an increase in indirect bilirubin and may cause serious complications, such as acute renal failure. Hepatocellular jaundice is mainly caused by various viral hepatitis, such as viral hepatitis B, viral hepatitis C, and may be caused by viral B or cytomegalovirus infection, and cirrhosis of the liver can also cause indirect bilirubin elevation. These diseases can cause ascites, hypersplenism, esophagogastric fundus varices, spontaneous peritonitis, hepatorenal syndrome, which can lead to a serious impact on the survival of patients.