During the preoperative conversation with a hernia patient, the patient often asks: How long will the patch last? This is because the inserted patch, mainly the most commonly used synthetic patch, is a non-biodegradable material that eventually grows closely with the body’s own tissues after implantation and does not need to be removed for life as long as no infection, rejection or recurrence is encountered. The principle of non-biodegradable synthetic patch repair for hernia is to form a solid scar-like fibrous tissue complex centered on the patch in the defective area of the hernia. If too much scar-like fibrous connective tissue is formed, the patient often has a feeling of tightness, pulling or a foreign body feeling after surgery. Is there a material that will not leave a foreign body after repairing a hernia defect and will not become a foreign body for life? In recent years, with the development of material science, there are indeed patch materials that can be completely degraded and absorbed by the human body. These materials are not synthetic, but are derived from human or animal tissues or organs, and are processed and prepared after decellularization to release rejection. Since they are natural biological materials from nature, they are commonly referred to as biological patches in clinical practice. Some people ask, since it is completely absorbed and degraded by the body, the patch disappears in the body, so it is not a waste of patch? The answer is of course not. Here we have to explain the principle of biological patch to repair hernia, which is completely different from synthetic patch. While the bio-patch is degraded by the body, the body’s own cells, blood vessels and fibers will also enter into the bio-patch, and eventually the original patch is completely “replaced”, and the repaired area is remodeled and regenerated, theoretically forming a strong new barrier of the body itself, without any foreign substance remaining. This is indeed perfect in principle, so will it completely replace the synthetic patch as the first choice of hernia patients and surgeons? This is because there are still some shortcomings in the current biopatch. Theoretically, we expect the bio-complement to achieve the original or desired strength of the patch when it is completely replaced by the body, but this is not always the case. The remodeling ability of each individual is inconsistent, and individuals with poor remodeling ability may not be able to fully meet the strength needs of the repaired area, which is the first undesirable factor. Secondly, the new barrier formed after local remodeling will gradually become weaker as the body itself ages and degenerates, so in the long run, the local strength of the biopatch repair may have a tendency to decrease, which may lead to the recurrence of hernia in the future. Therefore, from a clinical point of view, according to the current situation of biopatch, it is true that in most cases doctors use synthetic patches, which are, after all, strong and relatively cheap because they are industrial synthetic materials. Biological patches are expensive, and to make a not so appropriate analogy, they are estimated to be comparable in price to the same area of gold leaf.