The main clinical significance of the atropine test is that it is used to aid in the diagnosis of sick sinus node syndrome. It is performed by first describing a set of electrocardiograms in the resting state, then atropine is injected quietly and the II-lead electrocardiograms are recorded for 1, 2, 3, 5, 10, 15, and 20 minutes. Clinically, the atropine test can be used to determine sinus node function. If, after administration of the drug, there is an inability to achieve sinus rhythm of more than 90 beats/min, or the presence of a junctional zone of the heart rate, as well as sinoatrial block and supraventricular tachycardia, the results of the atropine test are positive, which can assist in the diagnosis of pathological sinus node syndrome. In the process of use, must pay attention to the dosage, in order to prevent overuse and the phenomenon of atropine poisoning, atropine is an anticholinergic drug, poisoning will appear dry mouth, skin flushing, rapid heart rate, pupil dilation, blurred vision, severe respiratory paralysis and death, clinically available hairy fructovanilline or neostigmine to rescue the phenomenon. It should be noted that patients with glaucoma or prostate hypertrophy should be cautious. Specific examination methods should be carried out under medical advice.