Systolic pressure of 190mmHg and diastolic pressure of 100mmHg is associated with diet, genetics, and secondary diseases, and the main cause of pulse pressure difference greater than 60mmHg is hyperthyroidism, primary closure, and other diseases. The criteria for severe hypertension are systolic blood pressure greater than or equal to 180 mmHg, and/or diastolic blood pressure greater than or equal to 110 mmHg, systolic blood pressure of 190 mmHg, diastolic blood pressure of 100 mmHg, which is classified as grade 3 hypertension and can be categorized as either primary or secondary. Primary hypertension may be related to genetic factors, sleep apnea syndrome, secondary hypertension is usually caused by diseases, common diseases are renal diseases such as glomerulonephritis, renal artery stenosis, etc., endocrine diseases such as cortisolism, pheochromocytoma, hyperthyroidism and other diseases. Differential pulse pressure greater than 60mmHg is commonly caused by hyperthyroidism, aortic valve insufficiency, atherosclerosis and other diseases. The presence of hypertension and increased pulse pressure should be promptly consulted and treated under the guidance of a doctor.