The combination of Prilosec antihypertensive drugs with sartan is generally not recommended. Since both have similar mechanisms of action and the same treatment targets and contraindications, combining them produces an insignificant blood pressure-lowering effect, but side effects may increase. The mechanism of action of the two is similar in that both exert a blood pressure-lowering effect by inhibiting the RAAS system (renin-angiotensin-aldosterone system) in the body. The higher the level of angiotensin, the higher the blood pressure. Prilosec antihypertensive drugs are angiotensin-converting enzyme inhibitors, which can reduce part of the production of angiotensin, but can not block its production by other means. Sartans are angiotensin II receptor antagonists, which can directly block the formation of angiotensin II in all pathways. 1. Prilosec antihypertensive drugs are used in patients with hypertension with myocardial infarction, heart failure, atrial fibrillation, proteinuria, impaired glucose tolerance, and diabetic nephropathy. Common side effect is irritating dry cough. 2. Sartan antihypertensive drugs are suitable for hypertension accompanied by ventricular hypertrophy, heart failure, diabetic nephropathy, as well as patients with high uric acid gout, etc. Patients who have a dry cough on Prilosec are also suitable for sartan drugs. Adverse reactions directly related to the drug are fewer. Warm tips: the joint application of antihypertensive drugs must be under the guidance of a doctor’s application, not self medication.