Genital herpes virus (HSV) can be excreted from the epithelial cells of the male penis, and proper condom use can cover these areas of excretion, so condom use can reduce the risk of herpes virus infection in their sexual partners; while the female genital area has a larger area of excretion, their sexual partners will have a greater chance of herpes virus infection; in addition, both men and women with genital herpes can have multiple areas of excretion, so condom use may not completely prevent herpes virus infection, but may significantly reduce the risk of infection, and their role in preventing the disease still needs to be properly evaluated. It is emphasized that patients should inform their sexual partners about their disease, and by informing them in order to obtain their understanding and cooperation, avoid sexual contact when prodromal symptoms of recurrence or lesions appear, in order to reduce the risk of transmission of the herpes virus to their sexual partners. Due to the risk of asymptomatic transmission of the virus, condom use is encouraged throughout sexual intercourse and partner testing is recommended. Changing sexual behavior and eliminating multiple partners are now fundamental measures to prevent genital herpes.